Get over 150,000 points:
Strength upgrade
 
Get all golden Spiders  
Health upgrade
 
Finish the game and get level select: 
Some people do not know how to use level select. Just go to 
secrets turn level select on and during play press start then 
move the cursur over level select (the last one).Move the cursur 
left and right and click A when you've chosen the level you want 
to play.

Go to Specials/Cheats and enter the following codes:

 

   Action              Code

 

   Super coolant!                                      chillout

   Through the eyes of Spider-Man!         underthemask

   Send in the clowns!                              goestoyourhead

   Bigger isn't always better!                      spiderbyte

   Over-sized egos all around!                   joelspeanuts

   Spider-Man takes the red pill!                dodgethis

   Gimme all levels!                                    imiarmas

   Get me outta here!                                 romitas

   Spider-Man eats his spinach!                 koala

   Unlimited webbing!                                 organicwebbing

   ?                                       realhero

   ?                                       freakout

   ?                                       captainstacey

   ?                                       thugsrus

   ?                                       stickyrice

   ?                                       knuckles

   ?                                       serum

   ?                                       girlnextdoor

   ?                                       headexplody